Eastbound Panama Canal
Eastbound Panama Canal

Eastbound Panama Canal Cruise Guide

Embark on an Eastbound Panama Canal Cruise and experience the engineering marvel that is the Panama Canal. Our Eastbound Panama Canal cruises promise a thrilling adventure, taking you from the Pacific Ocean to the Atlantic Ocean. Sail through lush rainforests, marvel at the Gatun Locks, and explore historic cities like Cartagena, Colombia, or Puerto Vallarta, Mexico. As you traverse the locks and channels of the Panama Canal, you'll witness this incredible feat of human ingenuity while enjoying the comfort and luxury of our cruise ships. It's a journey filled with wonder, history, and the natural beauty of Central America. Join us on an Eastbound Panama Canal cruise and be part of this unforgettable experience.

Cartagena
Colon

Key Eastbound Panama Canal Cruise Information

Ships & Cruise Lines

A diverse array of ships navigates the Eastbound Panama Canal route, offering choices that cater to different travel styles and preferences. Major cruise lines like Celebrity Cruises, Holland America Line, and Cunard are prominent. The average cruise length of 17 nights means passengers spend significant time at sea, making onboard amenities crucial. You'll find everything from mega-ships like the Celebrity Ascent, which provides a modern luxury experience with expansive spas and numerous specialty dining venues, to more intimate, classic vessels like Cunard's Queen Elizabeth, which offers traditional elegance with formal nights and enrichment programs. The size of the ship matters: larger 'Neo-Panamax' ships utilize the canal's newer, larger locks, which is an experience in itself, while smaller ships may offer a more traditional transit experience through the original locks.

Ships best suited for this journey emphasize observation and enrichment. Vessels from lines like Holland America are renowned for their wraparound teak promenade decks, providing unobstructed, open-air viewing for the entire day-long canal transit. Many ships also feature forward-facing observation lounges, offering a climate-controlled vantage point. A key feature on these longer, destination-focused voyages is the onboard lecture series. Historians, engineers, and naturalists provide daily talks on the canal's construction, the region's geopolitics, and the diverse wildlife of the surrounding rainforests. These programs transform the long sea days into an integral part of the learning and discovery experience, making the journey as important as the destinations.

Last updated on June 20, 2025

Best Time to Cruise

The prime season for an Eastbound Panama Canal cruise is during the region's dry season, which runs from January through March. During these months, you can expect the most pleasant weather, with plentiful sunshine, lower humidity, and minimal rainfall. This makes for comfortable shore excursions, whether you're exploring ancient ruins or hiking in a rainforest. Wildlife, particularly migratory birds, is also abundant. As this is the peak tourist season, you should anticipate higher cruise fares and more crowded ships and ports. It's essential to pack lightweight clothing, a wide-brimmed hat, sunglasses, and high-SPF sunscreen to protect against the strong equatorial sun.

Alternatively, cruising during the shoulder months of September, October, and November can offer significant savings and fewer crowds. This period coincides with the rainy season, meaning you'll experience higher humidity and the likelihood of daily afternoon downpours. However, the rain also brings the landscapes to life, with incredibly lush and vibrant green foliage. While the Caribbean is in its hurricane season, Panama lies south of the main hurricane belt, making a direct hit on the canal unlikely, though itineraries can be affected in the Caribbean portion. If traveling during this time, packing a reliable rain jacket, waterproof footwear, and insect repellent is crucial. October is a particularly popular month for these repositioning cruises as lines move their fleets from Alaska and the West Coast to the Caribbean for the winter.

Last updated on June 20, 2025

Who Should Go

Eastbound Panama Canal cruises are exceptionally well-suited for mature travelers, retirees, and anyone with a flexible schedule that accommodates a longer voyage, typically 15 to 20 nights. The median price of around $123 per person per day is reasonable, but the overall cost for the extended trip appeals to those with a dedicated travel budget. This itinerary is a bucket-list item for history buffs, engineering aficionados, and geography lovers who are fascinated by the monumental achievement of the canal. The relaxed pace, with numerous sea days, is perfect for those who enjoy the onboard experience—attending lectures, reading by the pool, and enjoying leisurely dinners—as much as the port explorations.

The destination also appeals to travelers interested in a mix of culture, nature, and relaxation. Ports like Cartagena and Puerto Limon offer rich cultural and ecological experiences, from exploring historic cities to touring rainforests and coffee plantations. Activity levels can be tailored, though many popular excursions involve considerable walking, sometimes on uneven terrain like cobblestone streets. Travelers with mobility concerns should carefully review shore excursion details. This cruise is likely not the best fit for families with young children due to the long sea days and adult-oriented enrichment programs. Similarly, travelers seeking a high-energy, party-focused vacation might prefer a shorter Caribbean-only itinerary.

Last updated on June 20, 2025

Best Eastbound Panama Canal Cruise Deals

28 Night Seattle to Miami cruise
September 17, 2026
28 Night Seattle to Miami Cruise
CruiseScore™ (4.46/5)
Cunard Queen Elizabeth
S M L XL
Seattle Ketchikan Juneau Victoria Seattle Los Angeles Cabo San Lucas Puerto Quetzal Panama City Curacao Aruba Miami
$2,371
$85 per day
Outside
28 Night Seattle to Miami cruise
September 17, 2026
28 Night Seattle to Miami Cruise
CruiseScore™ (4.46/5)
Cunard Queen Elizabeth
S M L XL
Seattle Ketchikan Juneau Victoria Seattle Los Angeles Cabo San Lucas Puerto Quetzal Panama City Curacao Aruba Miami
$2,371
$85 per day
Outside
12 Night Ft. Lauderdale to Ft. Lauderdale cruise
December 5, 2026
Caribbean Princess
S M L XL
Ft. Lauderdale Georgetown Falmouth Cartagena Colon Puerto Limon Celebration Key Ft. Lauderdale
$984
$82 per day
Outside
12 Night Ft. Lauderdale to Ft. Lauderdale cruise
December 5, 2026
Caribbean Princess
S M L XL
Ft. Lauderdale Georgetown Falmouth Cartagena Colon Puerto Limon Celebration Key Ft. Lauderdale
$984
$82 per day
Outside
19 Night Seattle to Miami cruise
September 28, 2026
MSC Poesia
S M L XL
Seattle Los Angeles San Diego Cabo San Lucas Puntarenas Colon Cartagena Miami
$1,057
$56 per day
Outside
19 Night Seattle to Miami cruise
September 28, 2026
MSC Poesia
S M L XL
Seattle Los Angeles San Diego Cabo San Lucas Puntarenas Colon Cartagena Miami
$1,057
$56 per day
Outside
21 Night Seattle to Miami cruise
September 24, 2026
21 Night Seattle to Miami Cruise
CruiseScore™ (4.25/5)
Cunard Queen Elizabeth
S M L XL
Seattle Los Angeles Cabo San Lucas Puerto Quetzal Panama City Curacao Aruba Miami
$1,599
$76 per day
Inside
21 Night Seattle to Miami cruise
September 24, 2026
21 Night Seattle to Miami Cruise
CruiseScore™ (4.25/5)
Cunard Queen Elizabeth
S M L XL
Seattle Los Angeles Cabo San Lucas Puerto Quetzal Panama City Curacao Aruba Miami
$1,599
$76 per day
Inside
12 Night Ft. Lauderdale to Ft. Lauderdale cruise
November 23, 2026
Caribbean Princess
S M L XL
Ft. Lauderdale Aruba Cartagena Colon Puerto Limon Celebration Key Ft. Lauderdale
$1,054
$88 per day
Outside
12 Night Ft. Lauderdale to Ft. Lauderdale cruise
November 23, 2026
Caribbean Princess
S M L XL
Ft. Lauderdale Aruba Cartagena Colon Puerto Limon Celebration Key Ft. Lauderdale
$1,054
$88 per day
Outside
PRICE RISING
12 Night Ft. Lauderdale to Ft. Lauderdale cruise
October 30, 2026
Caribbean Princess
S M L XL
Ft. Lauderdale Curacao Cartagena Colon Puerto Limon Celebration Key Ft. Lauderdale
$984
$82 per day
Inside
PRICE RISING
12 Night Ft. Lauderdale to Ft. Lauderdale cruise
October 30, 2026
Caribbean Princess
S M L XL
Ft. Lauderdale Curacao Cartagena Colon Puerto Limon Celebration Key Ft. Lauderdale
$984
$82 per day
Inside
12 Night Ft. Lauderdale to Ft. Lauderdale cruise
November 11, 2026
Caribbean Princess
S M L XL
Ft. Lauderdale Aruba Cartagena Colon Puerto Limon Georgetown Ft. Lauderdale
$1,154
$96 per day
Outside
12 Night Ft. Lauderdale to Ft. Lauderdale cruise
November 11, 2026
Caribbean Princess
S M L XL
Ft. Lauderdale Aruba Cartagena Colon Puerto Limon Georgetown Ft. Lauderdale
$1,154
$96 per day
Outside
12 Night Ft. Lauderdale to Ft. Lauderdale cruise
January 22, 2027
Caribbean Princess
S M L XL
Ft. Lauderdale Aruba Cartagena Colon Puerto Limon Celebration Key Ft. Lauderdale
$1,094
$91 per day
Outside
12 Night Ft. Lauderdale to Ft. Lauderdale cruise
January 22, 2027
Caribbean Princess
S M L XL
Ft. Lauderdale Aruba Cartagena Colon Puerto Limon Celebration Key Ft. Lauderdale
$1,094
$91 per day
Outside
19 Night Los Angeles to New York cruise
October 13, 2026
Norwegian Bliss
S M L XL
Los Angeles Cabo San Lucas Acapulco Puerto Quetzal Puerto Caldera Cartagena Falmouth Miami New York
$2,549
$134 per day
Suite
19 Night Los Angeles to New York cruise
October 13, 2026
Norwegian Bliss
S M L XL
Los Angeles Cabo San Lucas Acapulco Puerto Quetzal Puerto Caldera Cartagena Falmouth Miami New York
$2,549
$134 per day
Suite
LOWEST PRICE EVER
24 Night Seattle to Miami cruise
September 28, 2026
24 Night MSC Grand Voyages
CruiseScore™ (3.81/5)
MSC Poesia
S M L XL
Seattle Los Angeles San Diego Cabo San Lucas Puntarenas Colon Cartagena Miami Georgetown Ocho Rios Miami
$1,348
$56 per day
Inside
LOWEST PRICE EVER
24 Night Seattle to Miami cruise
September 28, 2026
24 Night MSC Grand Voyages
CruiseScore™ (3.81/5)
MSC Poesia
S M L XL
Seattle Los Angeles San Diego Cabo San Lucas Puntarenas Colon Cartagena Miami Georgetown Ocho Rios Miami
$1,348
$56 per day
Inside

Last Minute Eastbound Panama Canal Cruises

28 Night Seattle to Miami cruise
September 17, 2026
28 Night Seattle to Miami Cruise
CruiseScore™ (4.46/5)
Cunard Queen Elizabeth
S M L XL
Seattle Ketchikan Juneau Victoria Seattle Los Angeles Cabo San Lucas Puerto Quetzal Panama City Curacao Aruba Miami
$2,371
$85 per day
Outside
28 Night Seattle to Miami cruise
September 17, 2026
28 Night Seattle to Miami Cruise
CruiseScore™ (4.46/5)
Cunard Queen Elizabeth
S M L XL
Seattle Ketchikan Juneau Victoria Seattle Los Angeles Cabo San Lucas Puerto Quetzal Panama City Curacao Aruba Miami
$2,371
$85 per day
Outside
19 Night Seattle to Miami cruise
September 28, 2026
MSC Poesia
S M L XL
Seattle Los Angeles San Diego Cabo San Lucas Puntarenas Colon Cartagena Miami
$1,057
$56 per day
Outside
19 Night Seattle to Miami cruise
September 28, 2026
MSC Poesia
S M L XL
Seattle Los Angeles San Diego Cabo San Lucas Puntarenas Colon Cartagena Miami
$1,057
$56 per day
Outside
21 Night Seattle to Miami cruise
September 24, 2026
21 Night Seattle to Miami Cruise
CruiseScore™ (4.25/5)
Cunard Queen Elizabeth
S M L XL
Seattle Los Angeles Cabo San Lucas Puerto Quetzal Panama City Curacao Aruba Miami
$1,599
$76 per day
Inside
21 Night Seattle to Miami cruise
September 24, 2026
21 Night Seattle to Miami Cruise
CruiseScore™ (4.25/5)
Cunard Queen Elizabeth
S M L XL
Seattle Los Angeles Cabo San Lucas Puerto Quetzal Panama City Curacao Aruba Miami
$1,599
$76 per day
Inside
LOWEST PRICE EVER
24 Night Seattle to Miami cruise
September 28, 2026
24 Night MSC Grand Voyages
CruiseScore™ (3.81/5)
MSC Poesia
S M L XL
Seattle Los Angeles San Diego Cabo San Lucas Puntarenas Colon Cartagena Miami Georgetown Ocho Rios Miami
$1,348
$56 per day
Inside
LOWEST PRICE EVER
24 Night Seattle to Miami cruise
September 28, 2026
24 Night MSC Grand Voyages
CruiseScore™ (3.81/5)
MSC Poesia
S M L XL
Seattle Los Angeles San Diego Cabo San Lucas Puntarenas Colon Cartagena Miami Georgetown Ocho Rios Miami
$1,348
$56 per day
Inside
22 Night Vancouver to Ft. Lauderdale cruise
September 23, 2026
Coral Princess
S M L XL
Vancouver San Francisco San Diego Los Angeles Puerto Vallarta Huatulco Puerto Chiapas Puntarenas Panama City Aruba Ft. Lauderdale
$3,159
$144 per day
Suite
22 Night Vancouver to Ft. Lauderdale cruise
September 23, 2026
Coral Princess
S M L XL
Vancouver San Francisco San Diego Los Angeles Puerto Vallarta Huatulco Puerto Chiapas Puntarenas Panama City Aruba Ft. Lauderdale
$3,159
$144 per day
Suite
LOWEST PRICE EVER
26 Night Seattle to Miami cruise
September 21, 2026
26 Night Grand Voyage
CruiseScore™ (4.05/5)
MSC Poesia
S M L XL
Seattle Ketchikan Sitka Juneau Victoria Seattle Los Angeles San Diego Cabo San Lucas Puntarenas Colon Cartagena Miami
$1,995
$77 per day
Outside
LOWEST PRICE EVER
26 Night Seattle to Miami cruise
September 21, 2026
26 Night Grand Voyage
CruiseScore™ (4.05/5)
MSC Poesia
S M L XL
Seattle Ketchikan Sitka Juneau Victoria Seattle Los Angeles San Diego Cabo San Lucas Puntarenas Colon Cartagena Miami
$1,995
$77 per day
Outside
PRICE RISING
23 Night Vancouver to Ft. Lauderdale cruise
September 27, 2026
Star Princess
S M L XL
Vancouver Vancouver Victoria San Francisco Los Angeles Cabo San Lucas Mazatlan Panama City Aruba Ft. Lauderdale
$2,396
$104 per day
Inside
PRICE RISING
23 Night Vancouver to Ft. Lauderdale cruise
September 27, 2026
Star Princess
S M L XL
Vancouver Vancouver Victoria San Francisco Los Angeles Cabo San Lucas Mazatlan Panama City Aruba Ft. Lauderdale
$2,396
$104 per day
Inside
PRICE RISING
21 Night Vancouver to Ft. Lauderdale cruise
September 27, 2026
21 Night Panama Canal Cruise
CruiseScore™ (4.79/5)
Holland America Nieuw Amsterdam
S M L XL
Vancouver San Francisco San Diego Puerto Vallarta Huatulco Puerto Chiapas Puerto Quetzal Acajutla Cartagena Half Moon Cay Ft. Lauderdale
$2,694
$128 per day
Inside
PRICE RISING
21 Night Vancouver to Ft. Lauderdale cruise
September 27, 2026
21 Night Panama Canal Cruise
CruiseScore™ (4.79/5)
Holland America Nieuw Amsterdam
S M L XL
Vancouver San Francisco San Diego Puerto Vallarta Huatulco Puerto Chiapas Puerto Quetzal Acajutla Cartagena Half Moon Cay Ft. Lauderdale
$2,694
$128 per day
Inside
PRICE RISING
33 Night Seattle to Miami cruise
September 24, 2026
33 Night Seattle to Miami Cruise
CruiseScore™ (4.38/5)
Cunard Queen Elizabeth
S M L XL
Seattle Los Angeles Cabo San Lucas Puerto Quetzal Panama City Curacao Aruba Miami San Juan St. John's St. Lucia Barbados St. Maarten Tortola Miami
$11,536
$350 per day
Suite
PRICE RISING
33 Night Seattle to Miami cruise
September 24, 2026
33 Night Seattle to Miami Cruise
CruiseScore™ (4.38/5)
Cunard Queen Elizabeth
S M L XL
Seattle Los Angeles Cabo San Lucas Puerto Quetzal Panama City Curacao Aruba Miami San Juan St. John's St. Lucia Barbados St. Maarten Tortola Miami
$11,536
$350 per day
Suite

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