Sao Paolo is served by the port of Santos, but isn't a cruise port. In total, the port of Santos serves as the port of embarkation for approximately sixty cruises yearly from MSC, Costa, and Cunard to South America, as well as other places.
On average Sao Paolo is moderately inexpensive compared to other ports. See the graph below for the monthly average cost per day (Cruises only depart from Sao Paolo between January and December). Sailings scheduled from Sao Paolo during the the peak season of winter are significantly more expensive than the the low season of spring.