Sao Paolo is served by the port of Santos, but is not a cruise port. In total, the port of Santos serves as the embarkation for just twenty-five sailings annually from MSC to South America, as well as other places.
On average Sao Paolo is somewhat affordable compared to other ports. Sailings leaving from Sao Paolo during the peak seasons of winter and fall are much more expensive than the the low season of spring. Check out the diagram below for the average cost per day by month (Cruises only depart from Sao Paolo between January and December).