Sao Paolo is not actually a cruise port, but is served by the port of Santos. Added up, the cruise port of Santos functions as the port of embarkation for around forty cruises yearly from both MSC and Costa to South America, as well as other places.
Overall sailings from Sao Paolo are moderately affordable compared to other ports. See the diagram below for the monthly average cost per day (cruises only depart from Sao Paolo between January and December). Cruises leaving from Sao Paolo during the peak seasons of winter and fall are considerably more expensive than the the low season of spring.
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