With cruises to the Mediterranean and Europe, Lisbon functions as the port of departure for only five annual sailings from MSC, Holland America, and Celebrity.
Sailings scheduled from Lisbon during the the peak season of spring are significantly more expensive than the the low season of fall. Overall Lisbon is somewhat expensive compared to other ports. Take a look at the graph below for the monthly average cost per day (cruises only depart from Lisbon between April and November).
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