15 Night from San Diego to Tampa on the Royal Caribbean Serenade of the Seas
Set sail with the Royal Caribbean Serenade of the Seas and prepare for fifteen nights of tropical cruising around the Caribbean from San Diego to Tampa!
This sailing is particularly exciting because you will exclusively visit exotic destinations like Puerto Quetzal, Fuerte Amador, and Puerto Vallarta. This route is a rare one for the Serenade of the Seas. As a matter of fact, this is the only time it's going to sail it!
We include all all entertainment, meals, taxes, and port fees in this, so that you can compare sailings easily. This price just dropped, so book quickly to reserve your stateroom before the price rises again! With a cost of less than $130 per day, this is a good deal.
The Royal Caribbean Serenade of the Seas
Over 2,100 passengers can comfortably travel on this top-rated Radiance class vessel, based in Mexico and the Caribbean and refurbished less than one year ago in 2025.
The Serenade of the Seas Royal Caribbean offers a casino, three jacuzzis, a spa, an outdoor movie theater, a basketball court, a gym, a ping pong table, and a solarium.
Your Itinerary
This itinerary consists of eight sea days and six days in port. Highlights include a long stop in Fuerte Amador as well as visits to very uncommon ports like Puerto Quetzal and Puerto Vallarta.
| Date | Port | Arrive | Depart |
|---|---|---|---|
| Thu, Oct 7 | San Diego, CA | 5:00pm | |
| Fri, Oct 8 | At Sea | ||
| Sat, Oct 9 | At Sea | ||
| Sun, Oct 10 | Puerto Vallarta, Mexico | 8:00am | 5:00pm |
| Mon, Oct 11 | At Sea | ||
| Tue, Oct 12 | At Sea | ||
| Wed, Oct 13 | Puerto Quetzal, Guatemala | 8:00am | 5:00pm |
| Thu, Oct 14 | At Sea | ||
| Fri, Oct 15 | Puntarenas, Costa Rica | 8:00am | 5:00pm |
| Sat, Oct 16 | At Sea | ||
| Sun, Oct 17 | Fuerte Amador, Panama (Panama City) | 6:00am | 6:00pm |
| Mon, Oct 18 | Cartagena, Colombia | 11:30am | 7:00pm |
| Tue, Oct 19 | At Sea | ||
| Wed, Oct 20 | Georgetown, Cayman Islands | 7:00am | 4:00pm |
| Thu, Oct 21 | At Sea | ||
| Fri, Oct 22 | Tampa, FL | 5:00am |
Alternate Sailings
The Serenade of the Seas sails this route once next year, but doesn't sail it this year. No other ship sails this exact same route. In the accompanying graphic you can see a visualization of when this ship sails as well as the relative price.
Book Your Cruise
Since being listed five months ago, The price of this sailing has varied between $1,947 and $2,059 for a stateroom, inclusive of taxes and port fees. The accompanying graph indicates the cost over time for each type of cabin. Now this itinerary is at its lowest price, so secure your cabin now before it rises.
Last Updated: Jul 17, 2026
Last Modified: Jul 13, 2026