11 Night from San Diego to Panama City on the Crystal Serenity
Settle in for eleven nights of exciting travel around the Caribbean when you embark on the Crystal Serenity from San Diego to Panama City.
Stopping in very uncommon cities such as San Juan del Sur, Zihuatanejo, and Manzanillo makes this cruise particularly exciting. This route is an uncommon one for the Serenity, As it sails it only once.
The price includes all meals, entertainment, taxes, and fees. No sneaky extra fees!
The Crystal Serenity
The Serenity Crystal, the flagship of Crystal's class, is a highly-rated class ship based in Europe that can carry comfortably more than 700 cruisers.
The Serenity Crystal offers guests a casino, a ping pong table, a gym, a spa, and a jacuzzi.
Your Itinerary
This cruise spends six days in port and four days at sea. Highlights include a long stop in Manzanillo plus visits to rare stops like San Juan del Sur and Zihuatanejo.
Alternate Sailings
The Serenity sails this route once next year, but doesn't sail it this year. No other ship sails this exact same route. In the accompanying graphic you can see a visualization of when this ship sails as well as the relative price for an outside cabin.
Book Your Cruise
Since being listed 4 days ago, the price of this sailing has remained right at $5,030 for an outside cabin. The accompanying graph shows the price over time for every type of cabin. Right now this cruise is at its lowest price, so lock in your outside room now before it goes up.
Last Updated: Jul 21, 2026
Last Modified: Jul 17, 2026