Rome is not actually a cruise port, but is served by the port of Civitavecchia. Combined, the cruise port of Civitavecchia is the fifth most popular port, departure point of over four hundred and sixty cruises every year from Norwegian, Cunard, Princess and more to the Mediterranean and Europe.
On average cruises from Rome are somewhat expensive compared to other ports. The graph below shows the monthly average cost per day for cruises from Rome. Cruises leaving from Rome during the the peak season of summer are considerably more expensive than the the low season of winter.