23 Night from Santiago to Ft. Lauderdale on the Crystal Serenity

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Settle in for twenty-three nights of refreshing sailing across the sea when you step aboard the Crystal Serenity from Santiago to Ft. Lauderdale.

This cruise is special because you'll only call on very uncommon stops such as Iquique, Guayaquil, and Santo Tomas de Castilla. This route is a special one for the Serenity, As it sails it just once.

This price is the total price for an outside cabin, including meals, entertainment, taxes, and fees. What makes this cruise special is that if you book now you can book a window outside cabin for the interior price!

Day 20: Cozumel
Day 15: Puerto Limon

The Crystal Serenity

Based in Europe and refurbished less than this year ago in 2026, more than 700 people can cruise on the Serenity Crystal, the top-rated namesake of Crystal's class.

The Serenity Crystal offers a ping pong table, a gym, a casino, a jacuzzi, and a spa.

Crystal Serenity
Day 17: Roatan

Your Itinerary

This cruise is made up of seven days at sea and fifteen port days. High points include visits to rare stops like Iquique and Santo Tomas de Castilla as well as long stops in Lima and Guayaquil.

Mon29November 29thMonday
7:00pm
Tue30November 30thTuesday
9:00am – 6:00pm
9:00am – 6:00pm
Wed1December 1stWednesday
At Sea
Thu2December 2ndThursday
8:00am – 6:00pm
8:00am – 6:00pm
Fri3December 3rdFriday
At Sea
Sat4December 4thSaturday
8:00am – 6:00pm
8:00am – 6:00pm
Sun5December 5thSunday
7:00am – 7:00pm
7:00am – 7:00pm
Mon6December 6thMonday
11:00am – 8:00pm
11:00am – 8:00pm
Tue7December 7thTuesday
At Sea
Wed8December 8thWednesday
7:00am – 7:00pm
Thu9December 9thThursday
At Sea
Fri10December 10thFridaySat11December 11thSaturday
5:00pm – 5:00pm5:00pm – 5:00pm
Sun12December 12thSunday
Panama Canal (Cruising)
Mon13December 13thMonday
8:00am – 6:00pm
Tue14December 14thTuesday
At Sea
Wed15December 15thWednesday
8:00am – 6:00pm
8:00am – 6:00pm
Thu16December 16thThursday
8:00am – 6:00pm
Fri17December 17thFriday
8:00am – 6:00pm
Sat18December 18thSaturdaySun19December 19thSunday
9:00am – 5:00pm
9:00am – 5:00pm9:00am – 5:00pm
Mon20December 20thMonday
8:00am – 6:00pm
8:00am – 6:00pm
Tue21December 21stTuesday
At Sea
Wed22December 22ndWednesday
7:00am
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Print your CruiseSheet (PDF) one page with the route, schedule, weather & a notes box for each day
November 29th, 2027 - Santiago to Ft. Lauderdale Cruise on the Crystal Serenity
Your Route
Day 6: Pisco
Day 10: Guayaquil
Day 7: Lima
Day 2: Coquimbo
Day 24: Ft. Lauderdale

Alternate Sailings

The Serenity sails this route once next year, but doesn't sail it this year. This is the only ship that sails this exact route. In the accompanying graphic you can see a visualization of when this ship sails as well as the relative price for an outside cabin.

Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec
2026
2027
2028
$10,100 $10,100
Sold Out

See every departure of this route →


Book Your Cruise

The accompanying graph shows the cost over time for every type of cabin. Since being listed 21 days ago, The price of this cruise has ranged between $10,100 and $10,180 for an outside room, inclusive of taxes and port charges. Today this itinerary is at its lowest price, so lock in your outside stateroom now before it goes up.

outside
balcony
suite
$10,100
$12,100
$11,400
$439.13/day
$495.65/day
$495.65/day
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Last Updated: Aug 7, 2026

Last Modified: Aug 3, 2026

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