Santiago is not actually a cruise port, but is served by the port of Valparaiso. In total, Valparaiso is the embarkation point for five cruises yearly from both Celebrity and MSC to South America.
Overall Santiago is somewhat expensive compared to other ports. Sailings scheduled from Santiago during the the peak season of winter are somewhat more expensive than the the low season of spring. The diagram below shows the monthly average cost per day for cruises from Santiago (Cruises only depart from Santiago between March and December).