Santiago is not actually a cruise port, but is served by the ports of Valparaiso and Valparaiso. Together, Valparaiso and Valparaiso functions as the embarkation for one sailings per year from both MSC and Celebrity to South America.
Sailings leaving from Santiago during the the peak season of spring are somewhat more expensive than the the low season of winter. On average Santiago is fairly expensive compared to other ports. See the graph below for the monthly average cost per day (Cruises only depart from Santiago between December and February).