Santiago is served by the ports of Valparaiso and Valparaiso, but is not a cruise port. Added up, the port of Valparaiso and Valparaiso is the departure port for only one cruises per year from both MSC and Celebrity to South America.
On average sailings from Santiago are rather expensive compared to other ports. Cruises leaving from Santiago during the the peak season of spring are much more expensive than the the low season of winter. The chart below shows the monthly average cost per day for cruises from Santiago (Cruises only depart from Santiago between February and March).