12 Night from Santiago to Panama City on the Crystal Serenity
Reserve your outside cabin on the Crystal Serenity and settle in for twelve nights of luxurious cruising across the sea from Santiago to Panama City!
This cruise is particularly exciting because you will exclusively stop in extremely rare destinations like Iquique, Guayaquil, and Salaverry. This route is a special one for the Serenity, As it sails it just once.
Don't miss out-- today you can get an outside outside cabin for the price of an inside one! This price is the total price for an outside cabin, including all meals, entertainment, port charges, and taxes.
The Crystal Serenity
The Serenity Crystal, based in and refurbished just this year ago in 2026, is the highly-rated namesake of Crystal's Serenity class and can house over 700 cruisers.
The Serenity Crystal offers a casino, a gym, a spa, a ping pong table, and a jacuzzi.
- Ship class
- Serenity
- Built
- 2003
- Refurbished
- 2026
- Guests
- 740
- Crew
- 655
- Length
- 820 ft
Your Itinerary
This itinerary includes four days at sea and seven days in port. Major features include long stops in Callao and Guayaquil as well as visits to once-in-a-lifetime stops like Iquique and Salaverry.
© OpenStreetMap · © ESA WorldCover
Book Your Cruise
Since being listed a few months ago, The cost of this sailing has fluctuated between $5,920 and $6,200 for an outside cabin, inclusive of taxes and port fees. Today this cruise is just $280 more than the all time low of $5,920 so reserve your outside cabin now before it goes up.
Photos show a typical cabin in each class. Layout and decor vary by category.
Resources
Add it to your calendar
Your departure and return dates in the calendar you already use.
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OutlookPrintable CruiseSheet
One page with the route, the day-by-day schedule, typical weather and a notes box for each day.
Stay connected on board
A GigSky eSIM works on the ship and ashore in the Americas and the Caribbean, so your phone just works without the ship's Wi‑Fi package.
Unlimited data for your 13 days $191.99 $163.19
500 MB a day at full speed, then 500 kbps; messaging, email and maps apps stay unlimited.
Alternate Sailings
The Serenity sails this route once next year, but doesn't sail it this year. No other ship sails this exact same route.
No other departures of this route are on sale right now.
Show alternate dates for this cruise → Show all cruises that sail this route →
Data as of Oct 27, 2026