12 Night from Santiago to Panama City on the Crystal Serenity
Reserve your outside cabin on the Crystal Serenity and settle in for twelve nights of luxurious cruising across the sea from Santiago to Panama City!
This cruise is particularly exciting because you will exclusively stop in extremely rare destinations like Iquique, Guayaquil, and Coquimbo. This route is a special one for the Serenity, As it sails it just once.
Don't miss out-- today you can get an outside outside cabin for the price of an inside one! This price is the total price for an outside cabin, including all meals, entertainment, port charges, and taxes.
The Crystal Serenity
Over 700 guests can travel on the top-rated namesake of the class, based in Europe and refurbished less than this year ago in 2026.
The Serenity Crystal wows guests with a casino, a gym, a ping pong table, a jacuzzi, and a spa.
Your Itinerary
This cruise is made up of four sea days and seven port days. Major features include visits to rare ports like Iquique and Coquimbo plus long stops in Lima and Guayaquil.
Alternate Sailings
The Serenity sails this route once next year, but doesn't sail it this year. No other ship sails this exact same route. In the accompanying graphic you can see a visualization of when this ship sails as well as the relative price for an outside cabin.
Book Your Cruise
Since being listed 21 days ago, The cost of this sailing has fluctuated between $5,920 and $6,000 for an outside cabin, inclusive of taxes and port fees. This graph displays the cost over time for the different classes of cabin. At only $80 more than the all time low of $5,920 now is a great time to reserve your outside cabin
Last Updated: Aug 7, 2026
Last Modified: Aug 3, 2026